Selective Y centromere inactivation triggers chromosome shattering in micronuclei and repair by non-homologous end joining

Selective Y centromere inactivation triggers chromosome shattering in micronuclei and repair by non-homologous end joining

Chromosome missegregation into a micronucleus can cause complex and localized genomic rearrangements known as chromothripsis, but the underlying mechanisms remain unresolved. Here we developed an inducible Y centromere-selective inactivation strategy by exploiting a CENP-A/histone H3 chimaera to dir...

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Bibliographic Details
Main Authors: Ly, Peter, Kim, Dong H., Shoshani, Ofer, Skaletsky, Helen, Fachinetti, Daniele, Cleveland, Don W., Teitz, Levi Shmuel, Page, David C
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Published: Springer Nature 2018
Online Access:http://hdl.handle.net/1721.1/116801
https://orcid.org/0000-0003-1783-2930
https://orcid.org/0000-0001-9920-3411

Internet

http://hdl.handle.net/1721.1/116801
https://orcid.org/0000-0003-1783-2930
https://orcid.org/0000-0001-9920-3411

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