Selective Y centromere inactivation triggers chromosome shattering in micronuclei and repair by non-homologous end joining
Chromosome missegregation into a micronucleus can cause complex and localized genomic rearrangements known as chromothripsis, but the underlying mechanisms remain unresolved. Here we developed an inducible Y centromere-selective inactivation strategy by exploiting a CENP-A/histone H3 chimaera to dir...
| Main Authors: | , , , , , , , |
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| Other Authors: | |
| Format: | Article |
| Published: |
Springer Nature
2018
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| Online Access: | http://hdl.handle.net/1721.1/116801 https://orcid.org/0000-0003-1783-2930 https://orcid.org/0000-0001-9920-3411 |