A Phase Separation Model for Transcriptional Control

Phase-separated multi-molecular assemblies provide a general regulatory mechanism to compartmentalize biochemical reactions within cells. We propose that a phase separation model explains established and recently described features of transcriptional control. These features include the formation of...

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Bibliographic Details
Main Authors: Hnisz, Denes, Young, Richard A., Chakraborty, Arup K., Sharp, Phillip A., Shrinivas, Krishna,Ph. D.Massachusetts Institute of Technology.
Other Authors: Massachusetts Institute of Technology. Institute for Medical Engineering & Science
Format: Article
Published: Elsevier 2018
Online Access:http://hdl.handle.net/1721.1/116858
https://orcid.org/0000-0002-4167-9385
https://orcid.org/0000-0001-8855-8647
https://orcid.org/0000-0003-1268-9602
https://orcid.org/0000-0003-1465-1691