Amino Acids Rather than Glucose Account for the Majority of Cell Mass in Proliferating Mammalian Cells

Cells must duplicate their mass in order to proliferate. Glucose and glutamine are the major nutrients consumed by proliferating mammalian cells, but the extent to which these and other nutrients contribute to cell mass is unknown. We quantified the fraction of cell mass derived from different nutri...

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Bibliographic Details
Main Authors: Johnson, Marc O., Rathmell, Jeffrey C., Steinhauser, Matthew L., Hosios, Aaron Marc, Hecht, Vivian Chaya, Danai, Laura V, Manalis, Scott R, Vander Heiden, Matthew G.
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Published: Elsevier BV 2018
Online Access:http://hdl.handle.net/1721.1/116920
https://orcid.org/0000-0002-7702-5877
https://orcid.org/0000-0003-4110-1388
https://orcid.org/0000-0002-8206-8003
https://orcid.org/0000-0001-5223-9433
https://orcid.org/0000-0002-6702-4192