Activation of a Metabolic Gene Regulatory Network Downstream of mTOR Complex 1

Activation of a Metabolic Gene Regulatory Network Downstream of mTOR Complex 1

Aberrant activation of the mammalian target of rapamycin complex 1 (mTORC1) is a common molecular event in a variety of pathological settings, including genetic tumor syndromes, cancer, and obesity. However, the cell-intrinsic consequences of mTORC1 activation remain poorly defined. Through a combin...

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Bibliographic Details
Main Authors: Düvel, Katrin, Yecies, Jessica L., Menon, Suchithra, Raman, Pichai, Triantafellow, Ellen, Ma, Qicheng, Gorski, Regina, Cleaver, Stephen, MacKeigan, Jeffrey P., Finan, Peter M., Murphy, Leon O., Manning, Brendan D., Lipovsky, Alex, Souza, Amanda, Vander Heiden, Matthew G., Clish, Clary
Other Authors: Broad Institute of MIT and Harvard
Format: Article
Published: Elsevier BV 2018
Online Access:http://hdl.handle.net/1721.1/116937
https://orcid.org/0000-0002-6702-4192

Internet

http://hdl.handle.net/1721.1/116937
https://orcid.org/0000-0002-6702-4192

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