Protein Kinase C α Is a Central Signaling Node and Therapeutic Target for Breast Cancer Stem Cells

Protein Kinase C α Is a Central Signaling Node and Therapeutic Target for Breast Cancer Stem Cells

The epithelial-mesenchymal transition program becomes activated during malignant progression and can enrich for cancer stem cells (CSCs). We report that inhibition of protein kinase C α (PKCα) specifically targets CSCs but has little effect on non-CSCs. The formation of CSCs from non-stem cells invo...

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Bibliographic Details
Main Authors: Lu, Haihui, Buikhuisen, Joyce, Soh, Boon Seng, Lim, Elgene, Reinhardt, Ferenc, Wu, Zhenhua Jeremy, Krall, Jordan A., Bierie, Brian, Guo, Wenjun, Chen, Xi, Liu, Xiaole Shirley, Brown, Myles, Lim, Bing, Tam, Wai Leong, Weinberg, Robert A
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Published: Elsevier 2018
Online Access:http://hdl.handle.net/1721.1/116947
https://orcid.org/0000-0002-0895-3557

Internet

http://hdl.handle.net/1721.1/116947
https://orcid.org/0000-0002-0895-3557

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