How Does Multistep Tumorigenesis Really Proceed?

Identifying the cancer cells-of-origin is of great interest, as it holds the potential to elucidate biologic mechanisms inherent in the normal cell state that have been co-opted to drive the oncogenic cell state. An emerging concept, proposed here, states that cancer stem cells, key players in cance...

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Bibliographic Details
Main Authors: Chaffer, Christine L., Weinberg, Robert A
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Published: American Association for Cancer Research (AACR) 2018
Online Access:http://hdl.handle.net/1721.1/116974
https://orcid.org/0000-0002-0895-3557