miR-9, a MYC/MYCN-activated microRNA, regulates E-cadherin and cancer metastasis

miR-9, a MYC/MYCN-activated microRNA, regulates E-cadherin and cancer metastasis

MicroRNAs (miRNAs) are increasingly implicated in regulating the malignant progression of cancer. Here we show that miR-9, which is upregulated in breast cancer cells, directly targets CDH1, the E-cadherin-encoding messenger RNA, leading to increased cell motility and invasiveness. miR-9-mediated E-...

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Bibliographic Details
Main Authors: Prabhala, Harsha, Mestdagh, Pieter, Muth, Daniel, Teruya-Feldstein, Julie, Westermann, Frank, Speleman, Frank, Vandesompele, Jo, Ma, Li-Jun, Young, Jennifer J, Pan, Elizabeth, Reinhardt, Ferenc, Onder, Tamer T, Valastyan, Scott John, Weinberg, Robert A
Other Authors: Broad Institute of MIT and Harvard
Format: Article
Published: Springer Nature 2018
Online Access:http://hdl.handle.net/1721.1/116977
https://orcid.org/0000-0002-0895-3557

Internet

http://hdl.handle.net/1721.1/116977
https://orcid.org/0000-0002-0895-3557

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