Enhanced efficacy of combined temozolomide and bromodomain inhibitor therapy for gliomas using targeted nanoparticles

Enhanced efficacy of combined temozolomide and bromodomain inhibitor therapy for gliomas using targeted nanoparticles

Effective treatment for glioblastoma (GBM) is limited by the presence of the blood-brain barrier (BBB) and rapid resistance to single agent therapies. To address these issues, we developed a transferrin-functionalized nanoparticle (Tf-NP) that can deliver dual combination therapies. Using intravital...

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Bibliographic Details
Main Authors: Vu Han, Tu-Lan, Balkanska-Sinclair, Elena, Floyd, Scott R, Lam, Fred Chiu-Lai, Morton, Stephen Winford, Wyckoff, Jeffrey, Vu-Han, Tu-Lan, Hwang, Mun Kyung, Maffa, Amanda, Yaffe, Michael B, Hammond, Paula T
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Published: Nature Publishing Group 2018
Online Access:http://hdl.handle.net/1721.1/116978
https://orcid.org/0000-0002-9801-5037
https://orcid.org/0000-0003-1468-8275
https://orcid.org/0000-0002-9547-3251

Internet

http://hdl.handle.net/1721.1/116978
https://orcid.org/0000-0002-9801-5037
https://orcid.org/0000-0003-1468-8275
https://orcid.org/0000-0002-9547-3251

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