Enhanced efficacy of combined temozolomide and bromodomain inhibitor therapy for gliomas using targeted nanoparticles

Enhanced efficacy of combined temozolomide and bromodomain inhibitor therapy for gliomas using targeted nanoparticles

Effective treatment for glioblastoma (GBM) is limited by the presence of the blood-brain barrier (BBB) and rapid resistance to single agent therapies. To address these issues, we developed a transferrin-functionalized nanoparticle (Tf-NP) that can deliver dual combination therapies. Using intravital...

书目详细资料
Main Authors:	Vu Han, Tu-Lan, Balkanska-Sinclair, Elena, Floyd, Scott R, Lam, Fred Chiu-Lai, Morton, Stephen Winford, Wyckoff, Jeffrey, Vu-Han, Tu-Lan, Hwang, Mun Kyung, Maffa, Amanda, Yaffe, Michael B, Hammond, Paula T
其他作者:	Massachusetts Institute of Technology. Department of Biological Engineering
格式:	文件
出版:	Nature Publishing Group 2018
在线阅读:	http://hdl.handle.net/1721.1/116978 https://orcid.org/0000-0002-9801-5037 https://orcid.org/0000-0003-1468-8275 https://orcid.org/0000-0002-9547-3251

相似书籍

BRD4 prevents the accumulation of R-loops and protects against transcription–replication collision events and DNA damage
由: Lam, Fred C, et al.
出版: (2021)

MEOX2 promotes glioma growth and temozolomide chemoresistance
由: Tengfei Li, et al.
出版: (2024-09-01)

Impact of Temozolomide on Immune Response during Malignant Glioma Chemotherapy
由: Sadhak Sengupta, et al.
出版: (2012-01-01)

The bromodomain protein Brd4 insulates chromatin from DNA damage signalling
由: Floyd, Scott R., et al.
出版: (2014)

CHIP-mediated ubiquitin degradation of BCAT1 regulates glioma cell proliferation and temozolomide sensitivity
由: Zhuo Lu, et al.
出版: (2024-07-01)

Engineered bromodomains to explore the acetylproteome
由: Del Rosario, Amanda M, et al.
出版: (2016)

The landscape of circRNAs in gliomas temozolomide resistance: Insights into molecular pathways
由: Alireza Mafi, et al.
出版: (2024-12-01)

Preparation of transferrin-targeted temozolomide nano-micelles and their anti-glioma effect
由: Jun Yu, et al.
出版: (2024-09-01)

The efficacy and adverse events of bevacizumab combined with temozolomide in the treatment of glioma: a systemic review and meta-analysis of randomized controlled trials
由: SiYao Wei, et al.
出版: (2024-07-01)

Mechanism of in vitro sensitization of temozolomide to MGMT+ glioma cell line by FM19G11
由: FANG Huang-yi, YOU Chao-guo, PANG Chen, ZHANG Zhong-ding, ZHANG Zhe, KUANG Tong-shuai, SHENG Han-song
出版: (2021-04-01)

Apatinib combined with temozolomide in diffuse midline glioma: a novel and effective therapy
由: Yu-An Li, et al.
出版: (2024-06-01)

The nanoprodrug of polytemozolomide combines with MGMT siRNA to enhance the effect of temozolomide in glioma
由: Haoyue Xu, et al.
出版: (2023-12-01)

Long non-coding RNA in glioma: novel genetic players in temozolomide resistance
由: Jungwook Roh, et al.
出版: (2023-12-01)

Platycodin D Enhances Glioma Sensitivity to Temozolomide by Inhibition of the Wnt/β-Catenin Pathway
由: Li H, et al.
出版: (2025-03-01)

Elucidating cytotoxic effects of quercus infectoria gall extract on temozolomide-resistant glioma cells
由: Muhamad, Norhazilah
出版: (2023)

Two decades of progress in glioma methylation research: the rise of temozolomide resistance and immunotherapy insights
由: Xianhao Huo, et al.
出版: (2024-09-01)

Magnet-Guided Temozolomide and Ferucarbotran Loaded Nanoparticles to Enhance Therapeutic Efficacy in Glioma Model
由: Reju George Thomas, et al.
出版: (2024-05-01)

Folic acid‐decorated astrocytes‐derived exosomes enhanced the effect of temozolomide against glioma
由: Hong‐Ming Liu, et al.
出版: (2024-05-01)

Case report: Temozolomide induced hypermutation indicates an unfavorable response to immunotherapy in patient with gliomas
由: Jiapeng Liu, et al.
出版: (2024-04-01)

Correction: Apatinib combined with temozolomide in diffuse midline glioma: a novel and effective therapy
由: Yu-An Li, et al.
出版: (2024-07-01)

IL-18, a therapeutic target for immunotherapy boosting, promotes temozolomide chemoresistance via the PI3K/AKT pathway in glioma
由: Huangyi Ji, et al.
出版: (2024-10-01)

Nanoplatelets modified with RVG for targeted delivery of miR-375 and temozolomide to enhance gliomas therapy
由: Tingting Yang, et al.
出版: (2024-10-01)

GINS2 regulates temozolomide chemosensitivity via the EGR1/ECT2 axis in gliomas
由: Hua He, et al.
出版: (2024-03-01)

Mammalian target of rapamycin inhibition protects glioma cells from temozolomide-induced cell death
由: Benedikt Sauer, et al.
出版: (2024-01-01)

Selective targeting of bromodomains of the bromodomain-PHD fingers family impairs osteoclast differentiation
由: Meier, JC, et al.
出版: (2017)

Enhancing glioma treatment with 3D scaffolds laden with upconversion nanoparticles and temozolomide in orthotopic mouse model
由: Tatiana A. Mishchenko, et al.
出版: (2024-10-01)

Shadow study: randomized comparison of clinic with video follow-up in glioma undergoing adjuvant temozolomide therapy
由: Vijay M Patil, et al.
出版: (2018-04-01)

Propyl Gallate Exerts an Antimigration Effect on Temozolomide-Treated Malignant Glioma Cells through Inhibition of ROS and the NF-κB Pathway
由: Jen-Tsung Yang, et al.
出版: (2017-01-01)

BET bromodomain ligands: Probing the WPF shelf to improve BRD4 bromodomain affinity and metabolic stability
由: Jennings, L, et al.
出版: (2018)

The bromodomain interaction module.
由: Filippakopoulos, P, et al.
出版: (2012)

The bromodomain interaction module
由: Filippakopoulos, P, et al.
出版: (2012)

Bromodomains as therapeutic targets.
由: Muller, S, et al.
出版: (2011)

Hydrophobic Waters in Bromodomains
由: Serena G. Piticchio, et al.
出版: (2019-08-01)

A Dot-Blot Screening for Identifying the Temozolomide-Regulated Proteins as Potential Targets for Glioma Multi-OMICS Studies
由: Anna Maria Bielecka-Wajdman, et al.
出版: (2024-10-01)

UBE2C enhances temozolomide resistance by regulating the expression of p53 to induce aerobic glycolysis in glioma
由: Zhou Kun, et al.
出版: (2024-04-01)

Hypoxic microenvironment-induced exosomes confer temozolomide resistance in glioma through transfer of pyruvate kinase M2
由: Guofu Li, et al.
出版: (2024-04-01)

Importance of Autophagy Regulation in Glioblastoma with Temozolomide Resistance
由: Young Keun Hwang, et al.
出版: (2024-08-01)

Temozolomide-Induced Myelodysplasia
由: Ethan A. Natelson, et al.
出版: (2010-01-01)

Selective inhibition of BET bromodomains.
由: Filippakopoulos, P, et al.
出版: (2010)

Selective inhibition of BET bromodomains.
由: Filippakopoulos, P, et al.
出版: (2010)