Insulated Neighborhoods: Structural and Functional Units of Mammalian Gene Control

Understanding how transcriptional enhancers control over 20,000 protein-coding genes to maintain cell-type-specific gene expression programs in all human cells is a fundamental challenge in regulatory biology. Recent studies suggest that gene regulatory elements and their target genes generally occu...

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Bibliographic Details
Main Authors: Hnisz, Denes, Day, Daniel S., Young, Richard A.
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Published: Elsevier 2018
Online Access:http://hdl.handle.net/1721.1/116984
https://orcid.org/0000-0001-8855-8647