Functional Association of Gdown1 with RNA Polymerase II Poised on Human Genes
Most human genes are loaded with promoter-proximally paused RNA polymerase II (Pol II) molecules that are poised for release into productive elongation by P-TEFb. We present evidence that Gdown1, the product of the POLR2M gene that renders Pol II responsive to Mediator, is involved in Pol II elongat...
Main Authors: | Cheng, Bo, Li, Tiandao, Rahl, Peter B., Adamson, Todd E., Loudas, Nicholas B., Guo, Jiannan, Varzavand, Katayoun, Cooper, Jeffrey J., Hu, Xiaopeng, Gnatt, Averell, Price, David H., Young, Richard A. |
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Other Authors: | Massachusetts Institute of Technology. Department of Biology |
Format: | Article |
Published: |
Elsevier
2018
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Online Access: | http://hdl.handle.net/1721.1/116987 https://orcid.org/0000-0001-8855-8647 |
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