Combination PI3K/MEK inhibition promotes tumor apoptosis and regression in PIK3CA wild-type, KRAS mutant colorectal cancer

Combination PI3K/MEK inhibition promotes tumor apoptosis and regression in PIK3CA wild-type, KRAS mutant colorectal cancer

PI3K inhibition in combination with other agents has not been studied in the context of PIK3CA wild-type, KRAS mutant cancer. In a screen of phospho-kinases, PI3K inhibition of KRAS mutant colorectal cancer cells activated the MAPK pathway. Combination PI3K/MEK inhibition with NVP-BKM120 and PD-0325...

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Bibliographic Details
Main Authors: Roper, Jatin, Sinnamon, Mark J., Coffee, Erin M., Belmont, Peter, Keung, Lily, Georgeon-Richard, Larissa, Wang, Wei Vivian, Faber, Anthony C., Yun, Jihye, Bronson, Roderick T., Martin, Eric S., Tsichlis, Philip N., Hung, Kenneth E., Yilmaz, Omer
Other Authors: Koch Institute for Integrative Cancer Research at MIT
Format: Article
Published: Elsevier 2018
Online Access:http://hdl.handle.net/1721.1/117053
https://orcid.org/0000-0002-7577-4612

Internet

http://hdl.handle.net/1721.1/117053
https://orcid.org/0000-0002-7577-4612

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