Cholesterol-binding site of the influenza M2 protein in lipid bilayers from solid-state NMR

The influenza M2 protein not only forms a proton channel but also mediates membrane scission in a cholesterol-dependent manner to cause virus budding and release. The atomic interaction of cholesterol with M2, as with most eukaryotic membrane proteins, has long been elusive. We have now determined t...

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Bibliographic Details
Main Authors: Sergeyev, Ivan V., Hong, Mei, Elkins, Matthew Ryan, Williams, Jonathan Kyle, Gelenter, Martin David, Dai, Peng, Kwon, Byungsu, Pentelute, Bradley L.
Other Authors: Massachusetts Institute of Technology. Department of Chemistry
Format: Article
Published: National Academy of Sciences (U.S.) 2018
Online Access:http://hdl.handle.net/1721.1/117075
https://orcid.org/0000-0003-4183-4979
https://orcid.org/0000-0002-7272-6885
https://orcid.org/0000-0002-6412-805X
https://orcid.org/0000-0002-4581-3473
https://orcid.org/0000-0002-1567-9672