Structural Basis for Asymmetric Conductance of the Influenza M2 Proton Channel Investigated by Solid-State NMR Spectroscopy
The influenza M2 protein forms an acid-activated proton channel that is essential for virus replication. The transmembrane H37 selects for protons under low external pH while W41 ensures proton conduction only from the N terminus to the C terminus and prevents reverse current under low internal pH....
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| Format: | Article |
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Elsevier BV
2018
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| Online Access: | http://hdl.handle.net/1721.1/117142 https://orcid.org/0000-0002-6358-0642 https://orcid.org/0000-0002-0022-2637 https://orcid.org/0000-0002-1567-9672 https://orcid.org/0000-0001-5255-5858 |