Studies of chain substitution caused sub-fibril level differences in stiffness and ultrastructure of wildtype and oim/oim collagen fibers using multifrequency-AFM and molecular modeling

Molecular alteration in type I collagen, i.e., substituting the α2 chain with α1 chain in tropocollagen molecule, can cause osteogenesis imperfecta (OI), a brittle bone disease, which can be represented by a mouse model (oim/oim). In this work, we use dual-frequency Atomic Force Microscopy (AFM) and...

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Bibliographic Details
Main Authors: Li, Tao, Rodriguez-Florez, Naiara, Shefelbine, Sandra, Zeng, Kaiyang, Chang, Shu-Wei, Buehler, Markus J, Dao, Ming
Other Authors: Massachusetts Institute of Technology. Department of Civil and Environmental Engineering
Format: Article
Published: Elsevier BV 2018
Online Access:http://hdl.handle.net/1721.1/117165
https://orcid.org/0000-0002-4173-9659
https://orcid.org/0000-0001-5372-385X