Nickel Sequestration by the Host-Defense Protein Human Calprotectin

The human innate immune protein calprotectin (CP, S100A8/S100A9 oligomer, calgranulin A/calgranulin B oligomer, MRP-8/MRP-14 oligomer) chelates a number of first-row transition metals, including Mn(II), Fe(II), and Zn(II), and can withhold these essential nutrients from microbes. Here we elucidate t...

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Bibliographic Details
Main Authors: Nakashige, Toshiki George, Zygiel, Emily Mikayla, Drennan, Catherine L, Nolan, Elizabeth Marie
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Published: American Chemical Society (ACS) 2018
Online Access:http://hdl.handle.net/1721.1/117267
https://orcid.org/0000-0002-6234-8155
https://orcid.org/0000-0001-5486-2755
https://orcid.org/0000-0002-6153-8803