Regulation and Dysregulation of Chromosome Structure in Cancer

Cancer arises from genetic alterations that produce dysregulated gene expression programs. Normal gene regulation occurs in the context of chromosome loop structures called insulated neighborhoods, and recent studies have shown that these structures are altered and can contribute to oncogene dysregu...

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Bibliographic Details
Main Authors: Hnisz, Denes, Schuijers, Jurian, Li, Charles Han, Young, Richard A.
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:en_US
Published: 2018
Online Access:http://hdl.handle.net/1721.1/117286
https://orcid.org/0000-0001-8091-6112
https://orcid.org/0000-0001-8855-8647