Regulation and Dysregulation of Chromosome Structure in Cancer
Cancer arises from genetic alterations that produce dysregulated gene expression programs. Normal gene regulation occurs in the context of chromosome loop structures called insulated neighborhoods, and recent studies have shown that these structures are altered and can contribute to oncogene dysregu...
| Main Authors: | , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | en_US |
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2018
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| Online Access: | http://hdl.handle.net/1721.1/117286 https://orcid.org/0000-0001-8091-6112 https://orcid.org/0000-0001-8855-8647 |
| _version_ | 1826198810987069440 |
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| author | Hnisz, Denes Schuijers, Jurian Li, Charles Han Young, Richard A. |
| author2 | Massachusetts Institute of Technology. Department of Biology |
| author_facet | Massachusetts Institute of Technology. Department of Biology Hnisz, Denes Schuijers, Jurian Li, Charles Han Young, Richard A. |
| author_sort | Hnisz, Denes |
| collection | MIT |
| description | Cancer arises from genetic alterations that produce dysregulated gene expression programs. Normal gene regulation occurs in the context of chromosome loop structures called insulated neighborhoods, and recent studies have shown that these structures are altered and can contribute to oncogene dysregulation in various cancer cells. We review the types of genetic and epigenetic alterations that influence neighborhood structures and contribute to gene dysregulation in cancer, present models for insulated neighborhoods associated with the most prominent human oncogenes, and discuss how such models may lead to further advances in cancer diagnosis and therapy. Keywords: chromosome structure; insulated neighborhood; oncogene regulation |
| first_indexed | 2024-09-23T11:10:02Z |
| format | Article |
| id | mit-1721.1/117286 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T11:10:02Z |
| publishDate | 2018 |
| record_format | dspace |
| spelling | mit-1721.1/1172862022-10-01T01:46:55Z Regulation and Dysregulation of Chromosome Structure in Cancer Hnisz, Denes Schuijers, Jurian Li, Charles Han Young, Richard A. Massachusetts Institute of Technology. Department of Biology Richard Young Li, Charles Han Young, Richard A Cancer arises from genetic alterations that produce dysregulated gene expression programs. Normal gene regulation occurs in the context of chromosome loop structures called insulated neighborhoods, and recent studies have shown that these structures are altered and can contribute to oncogene dysregulation in various cancer cells. We review the types of genetic and epigenetic alterations that influence neighborhood structures and contribute to gene dysregulation in cancer, present models for insulated neighborhoods associated with the most prominent human oncogenes, and discuss how such models may lead to further advances in cancer diagnosis and therapy. Keywords: chromosome structure; insulated neighborhood; oncogene regulation National Institutes of Health (U.S.) (Grant HG002668) 2018-08-06T18:23:59Z 2018-08-06T18:23:59Z 2018-03 Article http://purl.org/eprint/type/JournalArticle 2472-3428 http://hdl.handle.net/1721.1/117286 Hnisz, Denes et al. “Regulation and Dysregulation of Chromosome Structure in Cancer.” Annual Review of Cancer Biology 2, 1 (March 2018): 21–40 © 2018 Annual Reviews https://orcid.org/0000-0001-8091-6112 https://orcid.org/0000-0001-8855-8647 en_US https://doi.org/10.1146/annurev-cancerbio-030617-050134 Annual Review of Cancer Biology Creative Commons Attribution-Noncommercial-Share Alike http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf Prof. Young |
| spellingShingle | Hnisz, Denes Schuijers, Jurian Li, Charles Han Young, Richard A. Regulation and Dysregulation of Chromosome Structure in Cancer |
| title | Regulation and Dysregulation of Chromosome Structure in Cancer |
| title_full | Regulation and Dysregulation of Chromosome Structure in Cancer |
| title_fullStr | Regulation and Dysregulation of Chromosome Structure in Cancer |
| title_full_unstemmed | Regulation and Dysregulation of Chromosome Structure in Cancer |
| title_short | Regulation and Dysregulation of Chromosome Structure in Cancer |
| title_sort | regulation and dysregulation of chromosome structure in cancer |
| url | http://hdl.handle.net/1721.1/117286 https://orcid.org/0000-0001-8091-6112 https://orcid.org/0000-0001-8855-8647 |
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