The Dawn of the Age of Amino Acid Sensors for the mTORC1 Pathway

The mechanistic target of rapamycin complex 1 (mTORC1) is a master regulator of cell growth that responds to a diverse set of environmental inputs, including amino acids. Over the past 10 years, a number of proteins have been identified that help transmit amino acid availability to mTORC1. However,...

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Bibliographic Details
Main Authors: Wolfson, Rachel Laura, Sabatini, David
Other Authors: Koch Institute for Integrative Cancer Research at MIT
Format: Article
Published: Elsevier BV 2018
Online Access:http://hdl.handle.net/1721.1/117492
https://orcid.org/0000-0002-9535-7664
https://orcid.org/0000-0002-1446-7256