Cross-Cohort Analysis Identifies a TEAD4–MYCN Positive Feedback Loop as the Core Regulatory Element of High-Risk Neuroblastoma

Cross-Cohort Analysis Identifies a TEAD4–MYCN Positive Feedback Loop as the Core Regulatory Element of High-Risk Neuroblastoma

High-risk neuroblastomas show a paucity of recurrent somatic mutations at diagnosis. As a result, the molecular basis for this aggressive phenotype remains elusive. Recent progress in regulatory network analysis helped us elucidate disease-driving mechanisms downstream of genomic alterations, includ...

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Bibliographic Details
Main Authors: Rajbhandari, Presha, Lopez, Gonzalo, Capdevila, Claudia, Salvatori, Beatrice, Yu, Jiyang, Rodriguez-Barrueco, Ruth, Martinez, Daniel, Yarmarkovich, Mark, Weichert-Leahey, Nina, Alvarez, Mariano J., Iyer, Archana, Harenza, Jo Lynne, Oldridge, Derek, De Preter, Katleen, Koster, Jan, Asgharzadeh, Shahab, Seeger, Robert C., Wei, Jun S., Khan, Javed, Vandesompele, Jo, Mestdagh, Pieter, Versteeg, Rogier, Look, A. Thomas, Iavarone, Antonio, Lasorella, Anna, Silva, Jose M., Maris, John M., Califano, Andrea, Abraham, Brian Joseph, Young, Richard A.
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Published: American Association for Cancer Research 2018
Online Access:http://hdl.handle.net/1721.1/117503
https://orcid.org/0000-0001-8855-8647

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http://hdl.handle.net/1721.1/117503
https://orcid.org/0000-0001-8855-8647

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