AMPK promotes tolerance to Ras pathway inhibition by activating autophagy
Targeted inhibitors of oncogenic Ras (rat sarcoma viral oncogene)-Raf signaling have shown great promise in the clinic, but resistance remains a major challenge: 30% of tumors with pathway mutations do not respond to targeted inhibitors, and of the 70% that do respond, all eventually develop resista...
| Main Authors: | , , , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | en_US |
| Published: |
Nature Publishing Group
2018
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| Online Access: | http://hdl.handle.net/1721.1/117558 https://orcid.org/0000-0001-8572-4734 https://orcid.org/0000-0002-2988-0537 https://orcid.org/0000-0002-9703-1780 |