A CRISPR–Cas9-based gene drive platform for genetic interaction analysis in Candida albicans

A CRISPR–Cas9-based gene drive platform for genetic interaction analysis in Candida albicans

Candida albicans is the leading cause of fungal infections; yet, complex genetic interaction analysis remains cumbersome in this diploid pathogen. Here, we developed a CRISPR-Cas9-based 'gene drive array' platform to facilitate efficient genetic analysis in C. albicans. In our system, a mo...

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Bibliographic Details
Main Authors: Shapiro, Rebecca S., Chavez, Alejandro, Porter, Caroline B. M., Hamblin, Meagan, Kaas, Christian S., DiCarlo, James E., Zeng, Guisheng, Xu, Xiaoli, Revtovich, Alexey V., Kirienko, Natalia V., Wang, Yue, Church, George M., Collins, James J.
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Published: Nature Publishing Group 2018
Online Access:http://hdl.handle.net/1721.1/117583

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