Oxidation of phosphorothioate DNA modifications leads to lethal genomic instability

Oxidation of phosphorothioate DNA modifications leads to lethal genomic instability

Genomic modification by sulfur in the form of phosphorothioate (PT) is widespread among prokaryotes, including human pathogens. Apart from its physiological functions, PT sulfur has redox and nucleophilic properties that suggest effects on bacterial fitness in stressful environments. Here we show th...

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Bibliographic Details
Main Authors: You, Delin, Kellner, Stefanie M, DeMott, Michael S, Cheng, Ching Pin, Russell, Brandon S, Cao, Bo, Dedon, Peter C
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Published: Nature Publishing Group 2018
Online Access:http://hdl.handle.net/1721.1/117596
https://orcid.org/0000-0003-3224-7502
https://orcid.org/0000-0003-1615-1578
https://orcid.org/0000-0003-0011-3067

Internet

http://hdl.handle.net/1721.1/117596
https://orcid.org/0000-0003-3224-7502
https://orcid.org/0000-0003-1615-1578
https://orcid.org/0000-0003-0011-3067

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