Modeling Therapeutic Antibody-Small Molecule Drug-Drug Interactions Using a Three-Dimensional Perfusable Human Liver Coculture Platform

Modeling Therapeutic Antibody-Small Molecule Drug-Drug Interactions Using a Three-Dimensional Perfusable Human Liver Coculture Platform

Traditional in vitro human liver cell culture models lose key hepatic functions such as metabolic activity during short-term culture. Advanced three-dimensional (3D) liver coculture platforms offer the potential for extended hepatocyte functionality and allow for the study of more complex biologic i...

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Bibliographic Details
Main Authors: Cosgrove, P. A., Dunn, R. T., Stolz, D. B., Hamadeh, H., Afshari, C., McBride, H., Long, Thomas J, Griffith, Linda G
Other Authors: Massachusetts Institute of Technology. Biotechnology Process Engineering Center
Format: Article
Published: American Society for Pharmacology & Experimental Therapeutics (ASPET) 2018
Online Access:http://hdl.handle.net/1721.1/117604
https://orcid.org/0000-0002-1801-5548

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http://hdl.handle.net/1721.1/117604
https://orcid.org/0000-0002-1801-5548

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