Modeling Therapeutic Antibody-Small Molecule Drug-Drug Interactions Using a Three-Dimensional Perfusable Human Liver Coculture Platform

Modeling Therapeutic Antibody-Small Molecule Drug-Drug Interactions Using a Three-Dimensional Perfusable Human Liver Coculture Platform

Traditional in vitro human liver cell culture models lose key hepatic functions such as metabolic activity during short-term culture. Advanced three-dimensional (3D) liver coculture platforms offer the potential for extended hepatocyte functionality and allow for the study of more complex biologic i...

Full description

Bibliographic Details
Main Authors:	Cosgrove, P. A., Dunn, R. T., Stolz, D. B., Hamadeh, H., Afshari, C., McBride, H., Long, Thomas J, Griffith, Linda G
Other Authors:	Massachusetts Institute of Technology. Biotechnology Process Engineering Center
Format:	Article
Published:	American Society for Pharmacology & Experimental Therapeutics (ASPET) 2018
Online Access:	http://hdl.handle.net/1721.1/117604 https://orcid.org/0000-0002-1801-5548

Similar Items

Quantitative Assessment of Population Variability in Hepatic Drug Metabolism Using a Perfused Three-Dimensional Human Liver Microphysiological System
by: Kostrzewski, T., et al.
Published: (2018)

Antibody drug discovery: From Idea to Biotherapeutic Molecule
by: Davis, Katherine A. D
Published: (2016)

Perfused multiwell plate for 3D liver tissue engineering
by: Domansky, Karel, et al.
Published: (2014)

Engineering liver
by: Griffith, Linda G., et al.
Published: (2015)

Targeting small molecule drugs to T cells with antibody-directed cell-penetrating gold nanoparticles
by: Bekdemir, Ahmet, et al.
Published: (2019)

Microneedles for diagnosis and therapeutic drug monitoring
by: Thean, Jia Hui
Published: (2018)

Integrated Assessment of Diclofenac Biotransformation, Pharmacokinetics, and Omics-Based Toxicity in a Three-Dimensional Human Liver-Immunocompetent Coculture System
by: Large, Emma, et al.
Published: (2017)

Microbial therapeutics: New opportunities for drug delivery
by: Jimenez, Miguel, et al.
Published: (2020)

Development of antibody drug conjugates for cancer therapy
by: Alif Sufiyan Ali
Published: (2018)

Herb - Drug Interaction: The Effect Of Tinospora Crispa Miers. On Drug Metabolism In Rat Liver
by: Tan , Phaik Tin
Published: (2009)

Characterization of a perfused 3D liver bioreactor
by: Mitchel, Jennifer (Jennifer A.)
Published: (2008)

Meeting the oxygen requirements of an isolated perfused rat liver
by: Izamis, Maria-Louisa, 1979-
Published: (2010)

Metabolite profiling and pharmacokinetic evaluation of hydrocortisone in a perfused 3D human liver bioreactor
by: Sarkar, Ujjal, et al.
Published: (2015)

Increased differentiation properties in two- and three-dimensional coculture of hepatocytes and liver epithelial cells by a novel quantitative functional liver assay
by: Moritz, Joseph M. (Joseph Michael)
Published: (2009)

Liver ‘organ on a chip’
by: Beckwitt, Colin H., et al.
Published: (2019)

Quantitative analysis of cellular processing of Antibody-Drug Conjugates
by: Maass, Katie F
Published: (2016)

Synergistic drug-cytokine induction of hepatocellular death as an in vitro approach for the study of inflammation-associated idiosyncratic drug hepatotoxicity
by: Xu, Jinghai J., et al.
Published: (2011)

Primary liver cells cultured on carbon nanotube substrates for liver tissue engineering and drug discovery applications
by: Che Abdullah, Che Azurahanim, et al.
Published: (2014)

Effect of some antimalarial drugs on the liver: biochemical and histopathological studies
by: Al-Ani, Imad Matloub Dally, et al.
Published: (2013)

Lipids promote survival, proliferation, and maintenance of differentiation of rat liver sinusoidal endothelial cells in vitro
by: Hang, Ta-Chun, et al.
Published: (2014)

Capsaicin: current understanding in therapeutic effects, drug interaction, and bioavailability
by: Chan, Suk Huei, et al.
Published: (2020)

The possible potential therapeutic targets for drug induced gingival overgrowth
by: Subramani, Tamilselvan, et al.
Published: (2013)

Cytokine-associated drug toxicity in human hepatocytes is associated signaling network dysregulation
by: Hendriks, Bart S., et al.
Published: (2011)

Molecular dynamics of monoclonal antibody production in high density perfused bioreactors
by: Buser, Claudia Waltraut
Published: (2008)

The biochemical dynamics of monoclonal antibody production in high density perfused fermentors
by: Tyo, Michael Alexander.
Published: (2008)

Enhancing pharmaceutical formulations to improve efficacy and delivery of drug molecules
by: Weight, Alisha K. (Alisha Kessel)
Published: (2013)

An equipment selection methodology for continuous manufacturing of small-molecule drugs
by: Peng, Kevin,S. M.Massachusetts Institute of Technology.
Published: (2019)

Plasmodium falciparum protein kinase as a potential therapeutic target for antimalarial drugs development
by: Fauze Mahmud, et al.
Published: (2020)

Drug delivery systems based on iron oxide magnetite-layered double hydroxide nanoparticles for liver anti-cancer drugs
by: Ebadi, Mona
Published: (2021)

Therapeutic Drug Monitoring Service In Malaysia Current Practice And Cost Evaluation
by: Ahmed Abdelrahim, Hisham El Hag
Published: (2008)

Melatonergic Drugs for Therapeutic Use in Insomnia and Sleep Disturbances of Mood Disorders
by: Srinivasan, Venkatramanujam, et al.
Published: (2012)

Ex vivo perfusion optimization of donor liver grafts for transplantation and cell isolation
by: Izamis, Maria-Louisa, 1979-
Published: (2010)

Development of a high throughput 3D perfused liver tissue bioreactor
by: Inman, Samuel Walker
Published: (2007)

Characterization of the down regulation of antibody production in high cell density perfusion culture
by: Morrill, Joyce Catherine
Published: (2006)

Hydrogel Microparticle‐Templated Anti‐Solvent Crystallization of Small‐Molecule Drugs
by: Bora, Meghali, et al.
Published: (2025)

Identifying the proteins to which small-molecule probes and drugs bind in cells
by: Ong, Shao-En, et al.
Published: (2009)

Biology-inspired microphysiological systems to advance patient benefit and animal welfare in drug development
by: Griffith, Linda G, et al.
Published: (2022)

The effect of various drugs on the glucuronidation of zidovudine (azidothymidine; AZT) by human liver microsomes.
by: Sim, S.M., et al.
Published: (1991)

Three-dimensional artificial liver platforms for drug screening and tissue engineering applications
by: Ferracci, Gaia
Published: (2020)

Cost evaluation of therapeutic drug monitoring of gentamicin at a teaching hospital in Malaysia
by: Mohamed Ibrahim, Mohamed Izham, et al.
Published: (2014)