Quantitative Assessment of Population Variability in Hepatic Drug Metabolism Using a Perfused Three-Dimensional Human Liver Microphysiological System

Quantitative Assessment of Population Variability in Hepatic Drug Metabolism Using a Perfused Three-Dimensional Human Liver Microphysiological System

In this work, we first describe the population variability in hepatic drug metabolism using cryopreserved hepatocytes from five different donors cultured in a perfused three-dimensional human liver microphysiological system, and then show how the resulting data can be integrated with a modeling and...

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Bibliographic Details
Main Authors: Kostrzewski, T., Stokes, C. L., Hughes, D. J., Tsamandouras, Nikolaos, Griffith, Linda G, Cirit, Murat
Other Authors: Massachusetts Institute of Technology. Biotechnology Process Engineering Center
Format: Article
Published: American Society for Pharmacology & Experimental Therapeutics (ASPET) 2018
Online Access:http://hdl.handle.net/1721.1/117617
https://orcid.org/0000-0002-1801-5548

Internet

http://hdl.handle.net/1721.1/117617
https://orcid.org/0000-0002-1801-5548

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