Quantitative Assessment of Population Variability in Hepatic Drug Metabolism Using a Perfused Three-Dimensional Human Liver Microphysiological System
In this work, we first describe the population variability in hepatic drug metabolism using cryopreserved hepatocytes from five different donors cultured in a perfused three-dimensional human liver microphysiological system, and then show how the resulting data can be integrated with a modeling and...
| Main Authors: | , , , , , |
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| Other Authors: | |
| Format: | Article |
| Published: |
American Society for Pharmacology & Experimental Therapeutics (ASPET)
2018
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| Online Access: | http://hdl.handle.net/1721.1/117617 https://orcid.org/0000-0002-1801-5548 |