Interleukin-22 drives nitric oxide-dependent DNA damage and dysplasia in a murine model of colitis-associated cancer

Interleukin-22 drives nitric oxide-dependent DNA damage and dysplasia in a murine model of colitis-associated cancer

The risk of colon cancer is increased in patients with Crohn's disease and ulcerative colitis. Inflammation-induced DNA damage could be an important link between inflammation and cancer, although the pathways that link inflammation and DNA damage are incompletely defined. RAG2-deficient mice in...

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Bibliographic Details
Main Authors: Conaway, E A, Short, S P, Williams, C S, Horwitz, B H, Wang, Chuanwu, Gong, Guanyu, Sheh, Alexander, Muthupalani, Sureshkumar, Bryant, Erin, Puglisi, Dylan A, Holcombe, Hilda R, Parry, Nicola, Bakthavatchalu, Vasudevan, Wogan, Gerald N, Tannenbaum, Steven R, Fox, James G
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Published: Springer Nature 2018
Online Access:http://hdl.handle.net/1721.1/117635
https://orcid.org/0000-0001-9850-161X
https://orcid.org/0000-0003-1738-6539
https://orcid.org/0000-0003-0771-9889
https://orcid.org/0000-0001-9307-6116

Internet

http://hdl.handle.net/1721.1/117635
https://orcid.org/0000-0001-9850-161X
https://orcid.org/0000-0003-1738-6539
https://orcid.org/0000-0003-0771-9889
https://orcid.org/0000-0001-9307-6116

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