Diacylglycerol kinase synthesized by commensal Lactobacillus reuteri diminishes protein kinase C phosphorylation and histamine-mediated signaling in the mammalian intestinal epithelium

Diacylglycerol kinase synthesized by commensal Lactobacillus reuteri diminishes protein kinase C phosphorylation and histamine-mediated signaling in the mammalian intestinal epithelium

Lactobacillus reuteri 6475 (Lr) of thehuman microbiome synthesizes histamine and can suppress inflammation via type 2 histamine receptor (H2R) activation in the mammalian intestine. Gut microbes such as Lr promote H2R signaling and may suppress H1R proinflammatory signaling pathways in parallel by u...

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Bibliographic Details
Main Authors: Ganesh, B P, Ayyaswamy, S, Fultz, R, Major, A, Haag, A, Venable, S, Hall, Alexandra E., Nelson, Jordan William, Esparza, Marcos A., Lugo, Michael T, Fox, James G, Versalovic, James, Whary, Mark T.
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Published: Springer Nature 2018
Online Access:http://hdl.handle.net/1721.1/117637
https://orcid.org/0000-0002-5138-2948
https://orcid.org/0000-0001-9307-6116

Internet

http://hdl.handle.net/1721.1/117637
https://orcid.org/0000-0002-5138-2948
https://orcid.org/0000-0001-9307-6116

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