DiSCoVERing Innovative Therapies for Rare Tumors: Combining Genetically Accurate Disease Models with In Silico Analysis to Identify Novel Therapeutic Targets

DiSCoVERing Innovative Therapies for Rare Tumors: Combining Genetically Accurate Disease Models with In Silico Analysis to Identify Novel Therapeutic Targets

We used human stem and progenitor cells to develop a genetically accurate novel model of MYC-driven Group 3 medulloblastoma. We also developed a new informatics method, Disease-model Signature versus Compound-Variety Enriched Response ("DiSCoVER"), to identify novel therapeutics that targe...

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Bibliographic Details
Main Authors: Hanaford, A. R., Price, A., Kahlert, U. D., Maciaczyk, J., Nikkhah, G., Dancik, V., Seashore-Ludlow, B., Viswanathan, V., Rees, M. G., Eberhart, C. G., Raabe, E. H., Archer, Tenley, Kim, Jong Wook, Ehrenberger, Tobias, Clemons, Paul A, Stewart, Michelle L., Shamji, Alykhan, Fraenkel, Ernest, Pomeroy, Scott L., Tamayo, Pablo, Schreiber, Stuart L., Mesirov, Jill P.
Other Authors: Massachusetts Institute of Technology. Institute for Medical Engineering & Science
Format: Article
Published: American Association for Cancer Research (AACR) 2018
Online Access:http://hdl.handle.net/1721.1/117638
https://orcid.org/0000-0001-7963-402X
https://orcid.org/0000-0002-3772-8156
https://orcid.org/0000-0001-9249-8181

Internet

http://hdl.handle.net/1721.1/117638
https://orcid.org/0000-0001-7963-402X
https://orcid.org/0000-0002-3772-8156
https://orcid.org/0000-0001-9249-8181

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