GPR4 deficiency alleviates intestinal inflammation in a mouse model of acute experimental colitis

GPR4 deficiency alleviates intestinal inflammation in a mouse model of acute experimental colitis

GPR4 is a proton-sensing G protein-coupled receptor that can be activated by extracellular acidosis. It has recently been demonstrated that activation of GPR4 by acidosis increases the expression of numerous inflammatory and stress response genes in vascular endothelial cells (ECs) and also augments...

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Bibliographic Details
Main Authors: Sanderlin, Edward J., Leffler, Nancy R., Lertpiriyapong, Kvin, Cai, Qi, Hong, Heng, Oswald, Joani Zary, Justus, Calvin R., Krewson, Elizabeth A., O’Rourke, Dorcas, Yang, Li V., Bakthavatchalu, Vasudevan, Fox, James G
Other Authors: Massachusetts Institute of Technology. Division of Comparative Medicine
Format: Article
Published: Elsevier 2018
Online Access:http://hdl.handle.net/1721.1/117655
https://orcid.org/0000-0001-9307-6116

Internet

http://hdl.handle.net/1721.1/117655
https://orcid.org/0000-0001-9307-6116

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