Failed Progenitor Specification Underlies the Cardiopharyngeal Phenotypes in a Zebrafish Model of 22q11.2 Deletion Syndrome

Failed Progenitor Specification Underlies the Cardiopharyngeal Phenotypes in a Zebrafish Model of 22q11.2 Deletion Syndrome

Microdeletions involving TBX1 result in variable congenital malformations known collectively as 22q11.2 deletion syndrome (22q11.2DS). Tbx1-deficient mice and zebrafish recapitulate several disease phenotypes, including pharyngeal arch artery (PAA), head muscle (HM), and cardiac outflow tract (OFT)...

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Bibliographic Details
Main Authors: Guner-Ataman, Burcu, González-Rosa, Juan Manuel, Shah, Harsh N., Jeffrey, Spencer, Abrial, Maryline, Burns, C. Geoffrey, Burns, Caroline E., Butty, Vincent L G, Boyer, Laurie Ann
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Published: Elsevier 2018
Online Access:http://hdl.handle.net/1721.1/117677
https://orcid.org/0000-0003-3491-4962

Internet

http://hdl.handle.net/1721.1/117677
https://orcid.org/0000-0003-3491-4962

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