A mixed antagonistic/synergistic miRNA repression model enables accurate predictions of multi-input miRNA sensor activity

MicroRNAs (miRNAs) regulate a majority of protein-coding genes, affecting nearly all biological pathways. However, the quantitative dimensions of miRNA-based regulation are not fully understood. In particular, the implications of miRNA target site location, composition rules for multiple target site...

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Bibliographic Details
Main Authors: Gam, Jeremy Jonathan, Babb, Jonathan, Weiss, Ron
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Published: Nature Publishing Group 2018
Online Access:http://hdl.handle.net/1721.1/117727
https://orcid.org/0000-0003-4600-0383
https://orcid.org/0000-0003-0396-2443