Antigen recognition-triggered drug delivery mediated by nanocapsule-functionalized cytotoxic T-cells
Cytotoxic T-Lymphocytes (CTLs) kill pathogen-infected or transformed cells following interaction of their T-cell receptors (TCRs) with foreign (e.g. virus-derived) peptides bound to MHC-I molecules on the target cell. TCR binding triggers CTLs to secrete perforin, which forms pores in the target cel...
Main Authors: | Mueller, Stephanie, Vrbanac, Vlad, Genel, Shy, Tager, Andrew M., Allen, Todd M., Jones, Richard Bradley, Kumari, Sudha, Walker, Bruce, Irvine, Darrell J |
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Other Authors: | Massachusetts Institute of Technology. Institute for Medical Engineering & Science |
Format: | Article |
Published: |
Elsevier BV
2018
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Online Access: | http://hdl.handle.net/1721.1/117770 https://orcid.org/0000-0003-4083-335X https://orcid.org/0000-0003-2705-7245 https://orcid.org/0000-0001-6122-9245 |
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