Antigen recognition-triggered drug delivery mediated by nanocapsule-functionalized cytotoxic T-cells

Cytotoxic T-Lymphocytes (CTLs) kill pathogen-infected or transformed cells following interaction of their T-cell receptors (TCRs) with foreign (e.g. virus-derived) peptides bound to MHC-I molecules on the target cell. TCR binding triggers CTLs to secrete perforin, which forms pores in the target cel...

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Bibliographic Details
Main Authors: Mueller, Stephanie, Vrbanac, Vlad, Genel, Shy, Tager, Andrew M., Allen, Todd M., Jones, Richard Bradley, Kumari, Sudha, Walker, Bruce, Irvine, Darrell J
Other Authors: Massachusetts Institute of Technology. Institute for Medical Engineering & Science
Format: Article
Published: Elsevier BV 2018
Online Access:http://hdl.handle.net/1721.1/117770
https://orcid.org/0000-0003-4083-335X
https://orcid.org/0000-0003-2705-7245
https://orcid.org/0000-0001-6122-9245