3D microfluidic ex vivo culture of organotypic tumor spheroids to model immune checkpoint blockade

Microfluidic culture has the potential to revolutionize cancer diagnosis and therapy. Indeed, several micro- devices are being developed specifically for clinical use to test novel cancer therapeutics. To be effective, these platforms need to replicate the continuous interactions that exist between...

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Bibliographic Details
Main Authors: Portell, Andrew, Larios, Dalia, Piel, Brandon P., Mathur, Natasha, Zhou, Chensheng, Coakley, Raven Vlahos, Bartels, Alan, Bowden, Michaela, Herbert, Zach, Gilhooley, Sean, Carter, Jacob, Cañadas, Israel, Thai, Tran C., Kitajima, Shunsuke, Chiono, Valeria, Paweletz, Cloud P., Jenkins, Russell W., Aref, Amir Reza, Ivanova, Elena, Campisi, Marco, Hill, Sarah J, Barbie, David, Kamm, Roger Dale
Other Authors: Institute for Medical Engineering and Science
Format: Article
Language:en_US
Published: Royal Society of Chemistry (RSC) 2018
Online Access:http://hdl.handle.net/1721.1/118112
https://orcid.org/0000-0002-9199-9459
https://orcid.org/0000-0002-7232-304X