Cytosolic Delivery of Proteins by Bioreversible Esterification

Cloaking its carboxyl groups with a hydrophobic moiety is shown to enable a protein to enter the cytosol of a mammalian cell. Diazo compounds derived from (p-methylphenyl)glycine were screened for the ability to esterify the green fluorescent protein (GFP) in an aqueous environment. Esterification o...

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Bibliographic Details
Main Authors: Lomax, Jo E., Mix, Kalie, Raines, Ronald T
Other Authors: Massachusetts Institute of Technology. Department of Chemistry
Format: Article
Language:en_US
Published: American Chemical Society 2018
Online Access:http://hdl.handle.net/1721.1/118315
https://orcid.org/0000-0002-2836-5744
https://orcid.org/0000-0001-7164-1719