Cytosolic Delivery of Proteins by Bioreversible Esterification
Cloaking its carboxyl groups with a hydrophobic moiety is shown to enable a protein to enter the cytosol of a mammalian cell. Diazo compounds derived from (p-methylphenyl)glycine were screened for the ability to esterify the green fluorescent protein (GFP) in an aqueous environment. Esterification o...
Main Authors: | Lomax, Jo E., Mix, Kalie, Raines, Ronald T |
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Other Authors: | Massachusetts Institute of Technology. Department of Chemistry |
Format: | Article |
Language: | en_US |
Published: |
American Chemical Society
2018
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Online Access: | http://hdl.handle.net/1721.1/118315 https://orcid.org/0000-0002-2836-5744 https://orcid.org/0000-0001-7164-1719 |
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