Rational Engineering and Characterization of an mAb that Neutralizes Zika Virus by Targeting a Mutationally Constrained Quaternary Epitope

Rational Engineering and Characterization of an mAb that Neutralizes Zika Virus by Targeting a Mutationally Constrained Quaternary Epitope

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Following the recent emergence of Zika virus (ZIKV), many murine and human neutralizing anti-ZIKV antibodies have been reported. Given the risk of virus escape mutants, engineering antibodies that target mutationally constrained epitopes with therapeutically relevant potencies can be valuable for co...

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Bibliographic Details
Main Authors: Watanabe, Satoru, Chan, Kuan Rong, Huan, Jia, Chionh, Yok Hian, Raguram, Aditya, McBee, Megan, Ong, Eugenia Z., Gan, Esther S., Tan, Hwee Cheng, Tyagi, Anu, Bhushan, Shashi, Lescar, Julien, Vasudevan, Subhash G., Ooi, Eng Eong, Tharakaraman, Kannan, Subramanian, Vidya, Quinlan, Devin Scott, Sasisekharan, Ram
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Published: Elsevier 2018
Online Access:http://hdl.handle.net/1721.1/118328
https://orcid.org/0000-0002-6977-7403
https://orcid.org/0000-0002-2085-7840

Internet

http://hdl.handle.net/1721.1/118328
https://orcid.org/0000-0002-6977-7403
https://orcid.org/0000-0002-2085-7840

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