Route of immunization defines multiple mechanisms of vaccine-mediated protection against SIV

Antibodies are the primary correlate of protection for most licensed vaccines; however, their mechanisms of protection vary, ranging from physical blockade to clearance via the recruitment of innate immunity. Here, we uncover striking functional diversity in vaccine-induced antibodies associated wit...

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Bibliographic Details
Main Authors: Ackerman, Margaret E., Pittala, Srivamshi, Broge, Thomas, Linde, Caitlyn, Suscovich, Todd J., Brown, Eric P., Bradley, Todd, Natarajan, Harini, Lin, Shu, Sassic, Jessica K., O’Keefe, Sean, Mehta, Nickita, Goodman, Derrick, Sips, Magdalena, Weiner, Joshua A., Tomaras, Georgia D., Haynes, Barton F., Bailey-Kellogg, Chris, Roederer, Mario, Alter, Galit, Lauffenburger, Douglas A, Das, Jishnu
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Language:en_US
Published: Nature Publishing Group 2018
Online Access:http://hdl.handle.net/1721.1/118387
https://orcid.org/0000-0002-0050-989X