Mapping a functional cancer genome atlas of tumor suppressors in mouse liver using AAV-CRISPR–mediated direct in vivo screening

Mapping a functional cancer genome atlas of tumor suppressors in mouse liver using AAV-CRISPR–mediated direct in vivo screening

Cancer genomics consortia have charted the landscapes of numerous human cancers. Whereas somemutations were found in classical oncogenes and tumor suppressors, others have not yet been functionally studied in vivo. To date, a comprehensive assessment of how these genes influence oncogenesis is lacki...

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Bibliographic Details
Main Authors: Wang, Guangchuan, Chow, Ryan D., Ye, Lupeng, Guzman, Christopher D., Dai, Xiaoyun, Dong, Matthew B., Zhang, Feng, Platt, Randall Jeffrey, Chen, Sidi, Sharp, Phillip A.
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Published: American Association for the Advancement of Science (AAAS) 2018
Online Access:http://hdl.handle.net/1721.1/118426
https://orcid.org/0000-0003-2782-2509
https://orcid.org/0000-0003-1465-1691

Internet

http://hdl.handle.net/1721.1/118426
https://orcid.org/0000-0003-2782-2509
https://orcid.org/0000-0003-1465-1691

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