Establishment of human pluripotent stem cell-derived pancreatic β-like cells in the mouse pancreas

Type 1 diabetes is characterized by autoimmune destruction of β cells located in pancreatic islets. However, tractable in vivo models of human pancreatic β cells have been limited. Here, we generated xenogeneic human pancreatic β-like cells in the mouse pancreas by orthotopic transplantation of stem...

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Bibliographic Details
Main Authors: Ma, Haiting, Wert, Katherine J., Shvartsman, Dmitry, Melton, Douglas A., Jaenisch, Rudolf
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Published: National Academy of Sciences (U.S.) 2018
Online Access:http://hdl.handle.net/1721.1/118469