Iterative optimization yields Mcl-1–targeting stapled peptides with selective cytotoxicity to Mcl-1–dependent cancer cells

Iterative optimization yields Mcl-1–targeting stapled peptides with selective cytotoxicity to Mcl-1–dependent cancer cells

Bcl-2 family proteins regulate apoptosis, and aberrant interactions of overexpressed antiapoptotic family members such as Mcl-1 promote cell transformation, cancer survival, and resistance to chemotherapy. Discovering potent and selective Mcl-1 inhibitors that can relieve apoptotic blockades is thus...

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Bibliographic Details
Main Authors: Bird, Gregory H., Ryan, Jeremy A., Godes, Marina, Pritz, Jonathan R., Letai, Anthony, Walensky, Loren D., Rezaei Araghi, Raheleh, Jenson, Justin Michael, Grant, Robert A, Keating, Amy E.
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Published: National Academy of Sciences (U.S.) 2018
Online Access:http://hdl.handle.net/1721.1/118480
https://orcid.org/0000-0001-7594-1823
https://orcid.org/0000-0003-1960-0447
https://orcid.org/0000-0002-5072-2867
https://orcid.org/0000-0003-4074-8980

Internet

http://hdl.handle.net/1721.1/118480
https://orcid.org/0000-0001-7594-1823
https://orcid.org/0000-0003-1960-0447
https://orcid.org/0000-0002-5072-2867
https://orcid.org/0000-0003-4074-8980

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