Iterative optimization yields Mcl-1–targeting stapled peptides with selective cytotoxicity to Mcl-1–dependent cancer cells
Bcl-2 family proteins regulate apoptosis, and aberrant interactions of overexpressed antiapoptotic family members such as Mcl-1 promote cell transformation, cancer survival, and resistance to chemotherapy. Discovering potent and selective Mcl-1 inhibitors that can relieve apoptotic blockades is thus...
Main Authors: | , , , , , , , , , |
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Format: | Article |
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National Academy of Sciences (U.S.)
2018
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Online Access: | http://hdl.handle.net/1721.1/118480 https://orcid.org/0000-0001-7594-1823 https://orcid.org/0000-0003-1960-0447 https://orcid.org/0000-0002-5072-2867 https://orcid.org/0000-0003-4074-8980 |