Osteoblasts remotely supply lung tumors with cancer-promoting SiglecF
Bone has a well-established role in advanced cancer. It provides a supportive microenvironment for the growth of metastatic cells that escape the primary tumor, which ultimately leads to loss of bone mass. Engblom et al. show that bone may also contribute to early-stage tumorigenesis through a mecha...
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| Format: | Article |
| Language: | en_US |
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American Association for the Advancement of Science (AAAS)
2018
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| Online Access: | http://hdl.handle.net/1721.1/118804 https://orcid.org/0000-0002-5224-7764 https://orcid.org/0000-0001-7603-8396 |
| _version_ | 1826210737585913856 |
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| author | Rickelt, Steffen Hynes, Richard O |
| author2 | Massachusetts Institute of Technology. Department of Biology |
| author_facet | Massachusetts Institute of Technology. Department of Biology Rickelt, Steffen Hynes, Richard O |
| author_sort | Rickelt, Steffen |
| collection | MIT |
| description | Bone has a well-established role in advanced cancer. It provides a supportive microenvironment for the growth of metastatic cells that escape the primary tumor, which ultimately leads to loss of bone mass. Engblom et al. show that bone may also contribute to early-stage tumorigenesis through a mechanism that leads to an increase in bone mass (see the Perspective by Zhang and Lyden). In mouse models of lung adenocarcinoma, primary tumor cells remotely activated bone-resident cells called osteoblasts, which have a bone-building function. The activated osteoblasts in turn triggered production of a certain type of neutrophil that infiltrates the primary tumor and promotes its growth. Patients with early-stage lung cancer were also found to have an increase in bone density, consistent with the findings in mice. |
| first_indexed | 2024-09-23T14:54:54Z |
| format | Article |
| id | mit-1721.1/118804 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T14:54:54Z |
| publishDate | 2018 |
| publisher | American Association for the Advancement of Science (AAAS) |
| record_format | dspace |
| spelling | mit-1721.1/1188042022-10-01T23:18:54Z Osteoblasts remotely supply lung tumors with cancer-promoting SiglecF Rickelt, Steffen Hynes, Richard O Massachusetts Institute of Technology. Department of Biology Koch Institute for Integrative Cancer Research at MIT Hynes Richard Rickelt, Steffen Hynes, Richard O Bone has a well-established role in advanced cancer. It provides a supportive microenvironment for the growth of metastatic cells that escape the primary tumor, which ultimately leads to loss of bone mass. Engblom et al. show that bone may also contribute to early-stage tumorigenesis through a mechanism that leads to an increase in bone mass (see the Perspective by Zhang and Lyden). In mouse models of lung adenocarcinoma, primary tumor cells remotely activated bone-resident cells called osteoblasts, which have a bone-building function. The activated osteoblasts in turn triggered production of a certain type of neutrophil that infiltrates the primary tumor and promotes its growth. Patients with early-stage lung cancer were also found to have an increase in bone density, consistent with the findings in mice. National Institutes of Health (U.S.) (Grant U54-CA163109) Howard Hughes Medical Institute Massachusetts Institute of Technology. Ludwig Center for Molecular Oncology (Postdoctoral Fellowship) 2018-10-30T15:20:06Z 2018-10-30T15:20:06Z 2017-12 Article http://purl.org/eprint/type/JournalArticle 0036-8075 1095-9203 http://hdl.handle.net/1721.1/118804 Engblom, Camilla, et al. “Osteoblasts Remotely Supply Lung Tumors with Cancer-Promoting SiglecF High Neutrophils.” Science, vol. 358, no. 6367, Dec. 2017, p. eaal5081. https://orcid.org/0000-0002-5224-7764 https://orcid.org/0000-0001-7603-8396 en_US http://dx.doi.org/10.1126/science.aal5081 Science Creative Commons Attribution-Noncommercial-Share Alike http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf American Association for the Advancement of Science (AAAS) Prof. Hynes via Courtney Crummett |
| spellingShingle | Rickelt, Steffen Hynes, Richard O Osteoblasts remotely supply lung tumors with cancer-promoting SiglecF |
| title | Osteoblasts remotely supply lung tumors with cancer-promoting SiglecF |
| title_full | Osteoblasts remotely supply lung tumors with cancer-promoting SiglecF |
| title_fullStr | Osteoblasts remotely supply lung tumors with cancer-promoting SiglecF |
| title_full_unstemmed | Osteoblasts remotely supply lung tumors with cancer-promoting SiglecF |
| title_short | Osteoblasts remotely supply lung tumors with cancer-promoting SiglecF |
| title_sort | osteoblasts remotely supply lung tumors with cancer promoting siglecf |
| url | http://hdl.handle.net/1721.1/118804 https://orcid.org/0000-0002-5224-7764 https://orcid.org/0000-0001-7603-8396 |
| work_keys_str_mv | AT rickeltsteffen osteoblastsremotelysupplylungtumorswithcancerpromotingsiglecf AT hynesrichardo osteoblastsremotelysupplylungtumorswithcancerpromotingsiglecf |