Coordinated Splicing of Regulatory Detained Introns within Oncogenic Transcripts Creates an Exploitable Vulnerability in Malignant Glioma

Coordinated Splicing of Regulatory Detained Introns within Oncogenic Transcripts Creates an Exploitable Vulnerability in Malignant Glioma

Glioblastoma (GBM) is a devastating malignancy with few therapeutic options. We identify PRMT5 in an in vivo GBM shRNA screen and show that PRMT5 knockdown or inhibition potently suppresses in vivo GBM tumors, including patient-derived xenografts. Pathway analysis implicates splicing in cellular PRM...

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Bibliographic Details
Main Authors: Braun, Christian J., Stanciu, Monica, Boutz, Paul L., Patterson, Jesse C., Calligaris, David, Higuchi, Fumi, Neupane, Rachit, Fenoglio, Silvia, Cahill, Daniel P., Wakimoto, Hiroaki, Agar, Nathalie Y.R., Yaffe, Michael B., Sharp, Phillip A., Hemann, Michael T., Lees, Jacqueline A., Boutz, Paul, Patterson, Jesse C, Yaffe, Michael B, Hemann, Michael, Lees, Jacqueline, Braun, Christian Joerg
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Published: Elsevier BV 2018
Online Access:http://hdl.handle.net/1721.1/118828
https://orcid.org/0000-0002-5229-8748
https://orcid.org/0000-0002-7221-6041
https://orcid.org/0000-0003-0788-3136
https://orcid.org/0000-0003-1951-7803
https://orcid.org/0000-0002-2598-0098
https://orcid.org/0000-0002-9547-3251
https://orcid.org/0000-0003-1465-1691
https://orcid.org/0000-0001-9451-2194

Internet

http://hdl.handle.net/1721.1/118828
https://orcid.org/0000-0002-5229-8748
https://orcid.org/0000-0002-7221-6041
https://orcid.org/0000-0003-0788-3136
https://orcid.org/0000-0003-1951-7803
https://orcid.org/0000-0002-2598-0098
https://orcid.org/0000-0002-9547-3251
https://orcid.org/0000-0003-1465-1691
https://orcid.org/0000-0001-9451-2194

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