Coordinated Splicing of Regulatory Detained Introns within Oncogenic Transcripts Creates an Exploitable Vulnerability in Malignant Glioma
Glioblastoma (GBM) is a devastating malignancy with few therapeutic options. We identify PRMT5 in an in vivo GBM shRNA screen and show that PRMT5 knockdown or inhibition potently suppresses in vivo GBM tumors, including patient-derived xenografts. Pathway analysis implicates splicing in cellular PRM...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
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Elsevier BV
2018
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| Online Access: | http://hdl.handle.net/1721.1/118828 https://orcid.org/0000-0002-5229-8748 https://orcid.org/0000-0002-7221-6041 https://orcid.org/0000-0003-0788-3136 https://orcid.org/0000-0003-1951-7803 https://orcid.org/0000-0002-2598-0098 https://orcid.org/0000-0002-9547-3251 https://orcid.org/0000-0003-1465-1691 https://orcid.org/0000-0001-9451-2194 |