Directed evolution of broadly crossreactive chemokine-blocking antibodies efficacious in arthritis

Directed evolution of broadly crossreactive chemokine-blocking antibodies efficacious in arthritis

Chemokine receptors typically have multiple ligands. Consequently, treatment with a blocking antibody against a single chemokine is expected to be insufficient for efficacy. Here we show single-chain antibodies can be engineered for broad crossreactivity toward multiple human and mouse proinflammato...

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Bibliographic Details
Main Authors: Miyabe, Yoshishige, Miyabe, Chie, Luster, Andrew D., Angelini, Alessandro, Newsted, Daniel, Kwan, Byron Hua, Kelly, Ryan Lewis, Jamy, Misha N., Wittrup, Karl Dane
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Published: Nature Publishing Group 2018
Online Access:http://hdl.handle.net/1721.1/118861
https://orcid.org/0000-0001-5923-3843
https://orcid.org/0000-0002-9851-7029
https://orcid.org/0000-0001-5003-9104
https://orcid.org/0000-0003-2398-5896

Internet

http://hdl.handle.net/1721.1/118861
https://orcid.org/0000-0001-5923-3843
https://orcid.org/0000-0002-9851-7029
https://orcid.org/0000-0001-5003-9104
https://orcid.org/0000-0003-2398-5896

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