Directed evolution of broadly crossreactive chemokine-blocking antibodies efficacious in arthritis
Chemokine receptors typically have multiple ligands. Consequently, treatment with a blocking antibody against a single chemokine is expected to be insufficient for efficacy. Here we show single-chain antibodies can be engineered for broad crossreactivity toward multiple human and mouse proinflammato...
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Format: | Article |
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Nature Publishing Group
2018
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Online Access: | http://hdl.handle.net/1721.1/118861 https://orcid.org/0000-0001-5923-3843 https://orcid.org/0000-0002-9851-7029 https://orcid.org/0000-0001-5003-9104 https://orcid.org/0000-0003-2398-5896 |