Architecture of the human GATOR1 and GATOR1–Rag GTPases complexes

Architecture of the human GATOR1 and GATOR1–Rag GTPases complexes

Nutrients, such as amino acids and glucose, signal through the Rag GTPases to activate mTORC1. The GATOR1 protein complex - comprising DEPDC5, NPRL2 and NPRL3 - regulates the Rag GTPases as a GTPase-activating protein (GAP) for RAGA; loss of GATOR1 desensitizes mTORC1 signalling to nutrient starvati...

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Bibliographic Details
Main Authors: Shen, Kuang, Bomaliyamu, Aimaiti, Hong, Chuan, Yu, Zhiheng, Huang, Rick, Brignole, Edward J, Condon, Kendall Janine, Valenstein, Max L., Chantranupong, Lynne, Choe, Abigail D., Sabatini, David
Other Authors: Massachusetts Institute of Technology. Institute for Medical Engineering & Science
Format: Article
Published: Springer Nature 2018
Online Access:http://hdl.handle.net/1721.1/118864
https://orcid.org/0000-0002-4285-6128
https://orcid.org/0000-0002-9515-8892
https://orcid.org/0000-0001-9388-1633
https://orcid.org/0000-0002-1446-7256

Internet

http://hdl.handle.net/1721.1/118864
https://orcid.org/0000-0002-4285-6128
https://orcid.org/0000-0002-9515-8892
https://orcid.org/0000-0001-9388-1633
https://orcid.org/0000-0002-1446-7256

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