mTORC1 Activator SLC38A9 Is Required to Efflux Essential Amino Acids from Lysosomes and Use Protein as a Nutrient

mTORC1 Activator SLC38A9 Is Required to Efflux Essential Amino Acids from Lysosomes and Use Protein as a Nutrient

The mTORC1 kinase is a master growth regulator that senses many environmental cues, including amino acids. Activation of mTORC1 by arginine requires SLC38A9, a poorly understood lysosomal membrane protein with homology to amino acid transporters. Here, we validate that SLC38A9 is an arginine sensor...

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Bibliographic Details
Main Authors: Freinkman, Elizaveta, Wyant, Gregory Andrew, Abu-Remaileh, Monther, Wolfson, Rachel Laura, Chen, Walter W., Danai, Laura V, Vander Heiden, Matthew G., Sabatini, David
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Published: Elsevier 2018
Online Access:http://hdl.handle.net/1721.1/118941
https://orcid.org/0000-0003-4642-3706
https://orcid.org/0000-0002-9535-7664
https://orcid.org/0000-0002-7043-5013
https://orcid.org/0000-0002-8206-8003
https://orcid.org/0000-0002-6702-4192
https://orcid.org/0000-0002-1446-7256

Internet

http://hdl.handle.net/1721.1/118941
https://orcid.org/0000-0003-4642-3706
https://orcid.org/0000-0002-9535-7664
https://orcid.org/0000-0002-7043-5013
https://orcid.org/0000-0002-8206-8003
https://orcid.org/0000-0002-6702-4192
https://orcid.org/0000-0002-1446-7256

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